HESI A2 Biology Practice Test

The Health Education Systems, Inc. Admission Assessment (HESI A2) Biology Test consists of 25 questions related to General Knowledge, Water, Macromolecules, Metabolism, Cells, Cellular Respiration, Cellular Reproduction, Photosynthesis, Genetics, and DNA. Below you will find additional information and sample questions for each Biology subsection.

 

HESI A2 Biology Practice Test

 

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General Knowledge

This subsection of the test requires that you understand the five kingdom classification system, which is best memorized using the mnemonic, “King Phillip came over for good soup.” This stands for: Kingdom, Phylum, Class, Order, Family, Genus, and Species. You will also need to demonstrate your knowledge of the scientific method, as well as evolution, including natural selection, punctuated equilibrium, and gradualism. Below are a couple sample questions.

  1. What is the third part of an organism’s classification?
  2. True or False: Gradualism describes the process of evolution as involving long periods without significant change, or stasis.
  3. What is the fourth step in the scientific method?

The answer to the first question can be attained by remembering the King Phillip mnemonic mentioned above. The correct answer is class. The correct answer for the second question is False. Gradualism describes evolution as occurring steadily, or gradually, over time. Punctuated equilibrium, on the other hand, includes periods of stasis. The answer to the third question is performing the experiments based on earlier predictions.

Water

In this subsection, you may be required to demonstrate your knowledge of the properties of water, including specific heat, cohesion, adhesion, and solvency. Below are a few sample questions:

  1. Does water decrease or increase the temperature of a living organism?
  2. What is the chemical composition of water?
  3. True or False: Ice is the densest phase of water.

The answer to the first question is that water stabilizes internal temperatures in living organisms, allowing them to achieve homeostasis. The answer to the second question is H2O, or two atoms of hydrogen and one atom of oxygen. The third answer is False. Liquid water is the densest phase of water, which is why ice floats in water.

Macromolecules

This subsection covers anabolic reactions and the four basic macromolecules: carbohydrates, proteins, nucleic acids, and lipids. You may also see questions pertaining catabolic reactions and the four basic building blocks: monosaccharides, fatty acids, amino acids, and nucleotides. Below are a couple sample questions:

  1. Fill in the blank in the question below:
    • Carbohydrates are converted into ___ in order to provide energy.
  2. Of what does a fatty acid chain consist?

The answer to the first question is glucose, a result of the oxidation process of carbohydrates, from which most of a cell’s energy is derived. The answer to the second question is that a fatty acid chain is comprised of a carboxylic acid group on one end and a methyl group at the other end.

Hesi A2 Biology Practice Test

Metabolism

This subsection will require that you demonstrate your knowledge of metabolism. This includes answering questions related to metabolic pathways, anabolic reactions, and catabolic reactions. Below are a couple sample questions:

  1. True or False: An anabolic reaction consists of large molecules breaking into smaller molecules.
  2. The four basic building blocks resulting from catabolic reactions are:
      1. Monosaccharides, amino acids, fatty acids, and nucleotides
      2. Amino acids, fatty acids, macromolecules, and catalysts
      3. Polysaccharides, amino acids, fatty acids, and nucleotides

The answer to the first question is False. An anabolic reaction consists of smaller molecules building into larger, more complex molecules, or macromolecules. Catabolic reactions refers to large molecules breaking into smaller molecules. The answer to the second question is a. Monosaccharides, amino acids, fatty acids, and nucleotides.

The Cell

This subsection will require that you demonstrate your knowledge of the function and structure of cells, including nuclei, and chromosomes, as well as ribosomes, nuclear pores, nucleoplasm, cytoplasm, cell membranes, and other parts of the cell and related concepts. Below are a couple sample questions:

    1. The part of the cytoskeleton that is made of protein and helps support the cell is:
      1. Cytosol
      2. Cell membrane
      3. Microtubules
    1. The sacs used for storage in a cell, as well as digestion and waste, are called:
      1. Waste sacs
      2. Vacuoles
      3. Cell membranes

The answer to the first question is c. Microtubules. The answer to the second question is b. Vacuoles.

Cellular Respiration

This subsection will require that you demonstrate your understanding of metabolic reactions within a cell. This includes concepts such as the Krebs cycle, chemiosmosis, glycolysis, oxidation, aerobic respiration, anaerobic respiration, and fermentation. Below are a couple sample questions:

  1. True or False: The final electron acceptor in anaerobic respiration is oxygen
  2. The Krebs cycle refers to:
    • The citric acid cycle, or process of releasing stored energy via chemical reactions within aerobic organisms
  3. The Cori cycle, or the process of lactate production by anaerobic glycolysis

The first answer is False. The final electron acceptor in anaerobic respiration is not oxygen, which is why it is referred to as anaerobic. The second answer is a. The citric acid cycle, or process of releasing stored energy via chemical reactions within aerobic organisms.

Photosynthesis

This subsection will ask that you demonstrate your understanding of concepts related to the process of photosynthesis. This subsection may include questions related to glucose conversion, thylakoids, chlorophyll, and related processes and concepts. Below is a sample question:

    1. Photosynthesis involves:
      1. Carbon dioxide and water converting into glucose, not requiring light
      2. Carbon dioxide and water converting into glucose, requiring light
      3. Cyanobacteria converting chlorophyll into energy
      4. Cyanobacteria forming cellular respiration and glucose conversion

The correct answer is b. Carbon dioxide and water converting into glucose, requiring light. Chlorophyll is the pigment in plants that absorbs light, and cyanobacteria is an aquatic and photosynthetic bacteria.

Cellular Reproduction

The questions in this section may focus on such concepts and terms as mitosis, meiosis, gametes, chromatids, and haploids and diploids. Below are a couple sample questions:

  1. Which term refers to a cell with two sets of chromosomes (one from each parent)?
      1. Chromatids
      2. Haploid
      3. Diploid
      4. Cell cycle
  2. True or False: Gametes in humans are haploid

The answer to the first question is c. Diploid. If you look at the prefix of the word diploid, you get a clue that this word refers to two sets of chromosomes. The answer to the second question is True. Human gametes are haploid, because they contain half of a person’s genetic information.

Genetics

This subsection may contain questions related to Mendel’s Laws. This includes questions related to genes, genotype, phenotype, alleles, dominant and recessive traits, hybrid crosses and monohybrids, codominance and incomplete dominance, DNA mutations, and other related concepts. Below are a couple sample questions:

  1. True or False: Environmental factors may impact phenotypes

The Hardy-Weinberg principle refers to:

  1. The belief that both dominant and recessive allele frequencies will remain stable throughout successive generations of a population, as long as certain conditions are met
  2. The belief that both dominant and recessive allele frequencies will change dramatically throughout successive generations of a population, as long as certain conditions are met
  3. The belief that organisms that reproduce by sexual reproduction will engage in nonrandom mating, thereby causing changes in the frequency of alleles in a gene pool

The first answer is True. Polygenetic inheritance is a non-Mendelian concept that suggests environmental factors may impact phenotypes. The second answer is a. The belief that both dominant and recessive allele frequencies will remain stable throughout successive generations of a population, as long as certain conditions are met.

DNA

This subsection may contain questions related to DNA replication, base pairing, antiparallel replication, and functions of proteins in DNA replication, as well as other related concepts. Below are a couple sample questions:

  1. Semiconservative replication refers to:
    1. The fact that DNA replication involves nucleotides on lagging strands running in opposite directions
    2. DNA replication in general, because DNA replication involves two replicated copies of DNA that each contain a strand of the original parents’ DNA
    3. The transcription of RNA into DNA in an inverted manner
  2. True or False: The unwinding of DNA’s double-helix structure is facilitated by a protein called helicase.

The first answer is b. DNA replication in general, because DNA replication involves two replicated copies of DNA that each contain a strand of the original parents’ DNA. This is essentially the definition of semiconservative. The second answer is True. Helicase breaks apart the hydrogen bonds between corresponding base pairs.

Test Preparation

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by Mometrix Test Preparation | Last Updated: October 18, 2019